After intravenous administration of 1.5 million. Spiramycin the ME by a one-hour infusion of the maximum plasma concentration. The half-life is approximately 5 hours. When administered 1.5 ppm spiramycin every 8 hours the equilibrium concentration achieved by the end of the second.
Spiramycin penetrates and accumulates in phagocytes (neutrophils, monocytes and peritoneal and alveolar macrophages).
in humans, the drug concentration in phagocytes are quite high.
These characteristics explain the effects of spiramycin on intracellular bacteria. Spiramycin dianabol before and after does not penetrate into the cerebrospinal fluid, but diffuses into breast milk.
Plasma protein binding is low (approximately 10%).
Spiramycin is metabolized in the liver with the formation of active metabolites with unknown chemical structure.
Provided mainly with bile. Renal excretion of the active spiramycin is about 14% of the administered dose.
The drug dianabol before and after is intended to treat infections of the upper and lower respiratory tract in adults:
- Acute pneumonia.
- Chronic secondary infections of the upper and lower respiratory tract
- Infectious dependent asthma.
Hypersensitivity to spiramycin and other ingredients.
Dosing and Administration
The drug for use only in adult:. 1.5 million ME every 8 hours (4,500,000 ME per day.) By slow infusion. In the case of severe infections, the dosage can be doubled. As soon as the condition of the patient, the treatment should be continued by oral administration.
The contents of the vial is dissolved in 4 ml of water for injection. The drug is administered by slow intravenous infusion over 1 hour, at least 100 ml of 5% glucose. The duration of treatment depends on the severity and characteristics of the course of infection, the sensitivity of microflora and is determined individually by the attending physician.
Since the dianabol before and after active ingredient is not eliminated via the kidneys, patients with renal insufficiency, the dosing regimen should not be changed.
It is not recommended the use of spiramycin in patients with a deficiency of the enzyme glucose-6-phosphate dehydrogenase, referring to the possible occurrence of acute hemolysis. The introduction of the drug should be discontinued immediately in the event of any signs of allergic reactions.
Pregnancy and lactation
Pregnancy: Rovamitsin® can be administered to pregnant women. Lactation: Spiramycin is excreted in breast milk. If a nursing mother takes Rovamitsin® recommended during treatment to interrupt breastfeeding.
Rarely and moderately expressed irritation along the vein, which is only in exceptional cases may require discontinuation of treatment. Skin allergic reactions. Rarely paraesthesia extending yourself during treatment.
Interactions with other drugs
Levodopa: by inhibiting the absorption of carbidopa, levodopa plasma levels may vary. When concomitant administration of spiramycin necessary clinical monitoring and a change in the dosage of levodopa.It should be used with caution with ergot alkaloids.
There is no specific antidote. If you suspect an overdose, symptomatic therapy is recommended spiramycin.