From the side of hematopoiesis: often – anemia. On the part of metabolism: often – hypoglycemia, rarely – hyperlipidemia, worsening of diabetes, hypercholesterolaemia (2.1%), weight gain (3.7%), in rare cases – rapid and significant weight gain. On the part of the central nervous system SCHNS: common – headache. On the part of the cardiovascular system (CVS): very rarely – heart failure and pulmonary edema, peripheral edema. On the part of the gastrointestinal tract (GIT ): often – bloating, nausea, abdominal pain, dyspepsia; not often – vomiting, anorexia, constipation; very rarely – increased activity of “hepatic” enzymes, dianabol for sale in rare cases – fatal, but the presence of a causal relationship has not been established. Skin and skin: in rare cases – urticaria, angioedema.
When used in combination with a sulfonilmocheviny: From the side of hematopoiesis: rarely – anemia. On the part of metabolism: often hypoglycemia, weight gain (6.3%); rarely – hyperlipidemia, hypercholesterolemia (3.6%) hypertriglyceridemia; in rare cases – a rapid and significant increase in body weight. CNS: rarely – increased drowsiness, dizziness, paresthesia. From the CCC: rarely – heart failure and pulmonary edema. On the part of the respiratory system: rarely – shortness of breath. From the GI: not often – bloating, nausea, abdominal pain, increased appetite, very rarely increased activity of “hepatic” enzymes, in rare cases – fatal, but the presence of a causal relationship has not been established. skin and skin: no often – alopecia, skin rash; in rare cases, urticaria, angioedema. Other: rarely – increased fatigue, asthenia.
Peripheral edema often occur when receiving rosiglitazone in combination with metformin (4.4%).
Hypercholesterolemia is accompanied by an increase dianabol for sale cholesterol, total cholesterol and ratio remains unchanged. In general, these changes are slight in nature or can be moderate and usually did not require discontinuation of treatment.
Data on overdose bit, single reception 20 mg rosiglitazone was not accompanied by any symptoms.
In case of overdose, if necessary, carry out an appropriate symptomatic treatment.
Dialysis is not effective because of the high affinity of rosiglitazone with blood proteins.
Interaction with other drugs
Metabolism of rosiglitazone is carried out mainly with the participation role is less significant, and the interaction of rosiglitazone with substrates and inhibitors of the latter do not have clinical significance.
The probability of interaction with cerivastatin is low.
Paclitaxel blocks the metabolism of rosiglitazone, the simultaneous use of drugs requires caution.
Interaction with other oral hypoglycemic drugs has no clinical significance (metformin, glibenclamide, acarbose). Moderate alcohol consumption has no effect on glycemic control.
Clinically significant interactions with digoxin, warfarindianabol for sale, nifedipine , and ethinylestradiol noretindrolonom not observed. Nonsteroidal anti-inflammatory drugs promote fluid retention in the body, while the reception together with rosiglitazone.