The maximum concentration of active ingredient in the blood serum with topical cream on the skin is an average This amount does not exceed 0.5% of the average maximum serum concentration after oral administration of metronidazole 250 mg of metronidazole in the form of tablets. The peak concentration of active ingredient in blood serum after epicutaneous application dianabol results cream observed after 6-24 hours.
When applied topically the drug concentration at the site of application are significantly higher than in blood plasma.
Indications for use:
The treatment of rosacea.
Hypersensitivity to the active substance or one of the formulation ingredients.
Application of pregnancy and during breastfeeding
Clinical experience with topical metronidazole no pregnancy. In the case of oral metronidazole crosses the placental barrier and rapidly enters the fetal circulation. Following oral administration of metronidazole in rats or mice is not observed evidence of toxicity to the fetus body. Nevertheless, as the study of reproductive toxicity in animals is not always possible to predict response in humans, and because the oral administration of metronidazole some rodents have demonstrated its carcinogenic properties should be used during pregnancy only when there are clear indications after consultation with doctor.
after oral metronidazole passes into breast milk in concentrations similar to those found in plasma. Despite the fact that after topical application dianabol results in lactating women blood levels are significantly lower than after administration of metronidazole into the decision on the termination of breastfeeding or termination of use of the drug should be made based on an assessment of the importance of the drug to the mother and the risk to the fetus.
Dosage and administration:
For external use only.
Apply a thin layer of cream to previously cleaned affected areas of skin twice a day, morning and evening, to avoid getting the cream in the eyes, lips and mucous membranes of the nose.
The average duration of treatment is 3-4 months.
However, if there are clear signs of good therapy, your doctor may be considered to continue treating a patient for an additional 3 – 4 months, depending on the severity of the condition. In the absence of overt clinical improvement, treatment should be discontinued.
Patients older dose adjustment is required.
The drug dianabol results is not recommended for use in children due to lack of data on the safety and efficacy of the drug in patients in this age category.
When applying the have been reported following spontaneous reports of adverse events that are within each class divided by the frequency of occurrence of organ.
Disorders of the skin and subcutaneous tissue
Common: dry skin, erythema, itching, skin discomfort (burning sensation of the skin, skin pain / tingling), irritation of the skin, increasing incidence of rosacea
Frequency unknown: contact dermatitis, peeling of the skin, swelling of the face
Disorders of the nervous system
Uncommon: hypoesthesia, paresthesia, dysgeusia (metallic taste)
Disorders of the gastrointestinal tract
Uncommon: dianabol results Nausea
If any of these instructions side effects are compounded, or observed any other side effects not mentioned in the instructions, you should immediately inform your doctor. anapolin