One of the most important active metabolites dianabol side effects for men. Calcitriol promotes intestinal absorption of calcium and regulates bone mineralization. The pharmacological effect of a single dose of calcitriol lasts 3-5 days.
The key role of calcitriol in the regulation of calcium metabolism, which consists in stimulating osteoblast activity of the skeleton, is a reliable pharmacological basis for its therapeutic effect for osteoporosis.
In patients with severe renal insufficiency, synthesis of endogenous calcitriol is reduced or can even cease altogether. Lack of calcitriol plays a major role in the genesis of renal osteodystrophy.
In patients with renal osteodystrophy (synthetic calcitriol) normalizes reduced calcium absorption in the intestine and eliminates hypocalcemia, elevated levels of alkaline phosphatase and serum. It reduces pain in bones and muscles as well as eliminates the histological changes that occur in osteitis fibrosa and other violations of mineralization.
In patients with postoperative and idiopathic hypoparathyroidism and pseudohypoparathyreosis Rokaltrol reduces hypocalcaemia and its clinical manifestations.
Patients with dianabol side effects for menrickets concentration low serum calcitriol or completely absent. Given the lack endogenous synthesis of calcitriol kidney reception Rokaltrola can be seen in these patients as substitution therapy.
Patients rickets and hypophosphatemia with low calcitriol plasma treatment Rokaltrolom reduces canalicular excretion of phosphate in combination with the intake of phosphorus drugs normalizes bone development.
Rokaltrolom treatment also helps with other forms of rickets, for example, caused by neonatal hepatitis, biliary atresia, cystinosis, and nutritional deficiency of calcium and dianabol side effects for men.
Calcitriol is rapidly absorbed in the intestine. After a single oral administration of 0.25-1.0 mg Rokaltrola maximum serum concentration is achieved in 3-6 hours. If readmission equilibrium concentrations are achieved within 7 days, depending on the dose.
After a single oral administration of 0.5 mg Rokaltrola mean value of serum calcitriol concentration rose from an initial value 40.0 4.4 pg / ml and 60.0 4.4 pg / ml after 2 hours, and then dropped to 53.0 6.9 over 4 hours to 50.0 7.0 after 8 hours 4.6 to 44 at 12 hours and 41.5 5.1 pg / ml after 24 hours.
in the blood, calcitriol and other vitamin D metabolites are bound to specific plasma proteins.
it can be assumed that exogenous calcitriol crosses the placental barrier and into breast milk.
The half-life of calcitriol in dianabol side effects for men serum is 9-10 hours. However, the pharmacological effect of a single dose of calcitriol lasts at least 7 days. Calcitriol is excreted in the bile and undergoes enterohepatic circulation.Following intravenous administration to healthy volunteers labeled calcitriol within 24 hours about 27% of the radioactivity detected in the feces and about 7% – in urine. After oral administration of 1 mcg calcitriol healthy volunteers labeled about 10% of the total radioactivity found in the urine within 24 hours. On the 6th day after intravenous injection of labeled calcitriol found in the urine of 16%, and in feces – 49% of the total radioactivity.
Pharmacokinetics in special cases,
in patients with nephrotic syndrome or in patients on hemodialysis, serum calcitriol levels are reduced, while achieving maximum concentration slowed somewhat.
Confirmed postmenopausal osteoporosis; renal osteodystrophy in patients with chronic renal failure, particularly in hemodialysis; secondary hyperparathyroidism in patients with moderate to severe degree of chronic renal failure (pre-dialysis); postsurgical hypoparathyroidism; idiopathic hypoparathyroidism; pseudohypoparathyreosis; vitamin-D-dependent rickets; hypophosphatemic vitamin-D-resistant rickets dianabol side effects for men (phosphate diabetes). natco 30