As Rokaltrol has an activity, its side effects are similar to those that occur when an overdose. Hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia). Acute symptoms may include anorexia, headache, vomiting, gastralgia, intestinal colic, increased activity of “liver” enzymes, and constipation. Because of the short biological half-life of calcitriol serum calcium levels to normal in a few days after the cancellation dianabol stack, that is much faster than in treatment with vitamin D 3 .
Dystrophy, sensory disturbances may occur during chronic administration, fever, thirst, polyuria and dehydration , lethargy, growth retardation and urinary tract infections.
The frequency of each of the side effects described in clinical use Rokaltrola all the indications for 15 years, is very low (including hypercalcemia) and does not exceed 0.001%.
when both hypercalcemia and hyperphosphatemia can occur soft tissue calcification which is detected radiographically.
in patients with normal renal function, chronic hypercalcemia may lead to an increase in serum creatinine.
in sensitive individuals may develop a hypersensitivity reaction (itching, rash, urticaria, and rarely erythematous skin lesions).
Overdose Treatment of asymptomatic hypercalcaemia see. See “Instructions for use”. As Rokaltrol is a derivative of dianabol stack, it is characterized by the same symptoms of an overdose. Taking large doses of calcium and phosphate together with Rokaltrolom can cause similar symptoms. The development of hypercalcemia may contribute to the high content of calcium in the dialysate. The symptoms of acute poisoning in vitamin D: anorexia, headache, vomiting, and constipation. Chronic poisoning symptoms: dystrophy (weakness, loss of weight), sensory disturbances, possible fever with thirst, polyuria, dehydration, apathy , growth retardation and urinary tract infections. The consequences of hypercalcemia are a focal renal cortical calcification, infarction, lung and pancreas. Treatment of accidental overdose: immediate gastric lavage or cottage emetics to prevent further absorption. To launch the drug in the feces as a laxative mineral oil is used. It is recommended to re-determine the level of calcium in serum. If elevated levels of serum calcium is stored, you can assign phosphates and corticosteroids as well as measures to ensure adequate urine output.
Interactions with other drugs
Because calcitriol – one dianabol stack of the most important active metabolites of vitamin D 3 , in order to avoid possible additive effects and hypercalcemia during treatment Rokaltrolom should stop taking and its derivatives.
Patients need to strictly comply with dietary recommendations, particularly relating to consumer calcium, as well as to avoid the uncontrolled additional supplementation of calcium.
The simultaneous treatment of thiazide diuretics increases the risk of hypercalcemia. Patients receiving digitalis preparations, the dose of calcitriol must be chosen very carefully, because hypercalcemia they can trigger arrhythmias.
There is a functional antagonism between analogues, which enhance calcium absorption, and corticosteroids, which suppress.
Preparations containing magnesium (eg, antacids) can cause gipermagniemiya and therefore should not be administered to patients on chronic hemodialysis, during treatment Rokaltrolom.
Since dianabol stack affects phosphate transport in the intestines, the kidneys and the bones, the dose of drugs that bind phosphates, must be adjusted depending on the phosphate level in serum.
Application of enzymes such inducers as phenytoin or phenobarbital, may enhance metabolism and thus reduce the serum concentration of calcitriol, so while the use of these drugs may require more high doses of calcitriol.
Cholestyramine can reduce intestinal absorption of fat soluble vitamins and including calcitriol.